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Asst Research Scientist/Engin - Habelhah Laboratory

21001116 Requisition #

The University of Iowa Hospitals and Clinics department of Pathology is seeking an Assistant Research Scientist to conduct research focused on cell signaling, inflammation and cancer biology. The primary function of this position is to characterize how RIP1 regulates acute lung injury (ALI) induced by LPS in genetically engineered mouse models of ALI. The position is also expected to characterize the roles and mechanisms of the NF-kB signaling pathway in inflammation and tumor progression using xenograft mouse models of breast cancer. Tasks include the design, performance, and evaluation of experimental procedures with full responsibility for efficient use of resources and obtaining high-quality results in each individual study. Duties to include:


  • Perform mammalian cell culture and gene expression procedures
  • Purify protein using affinity chromatography
  • Perform in vitro immunokinase assays using 32P-g-APT
  • Perform invitro ubiquitination assays using 35S-Met-labeled substrates
  • Perform immunefluorescence staining and FACS analysis
  • Perform stable gene expression by retroviral or lentiviral infections
  • Characterize the roles of the TNF-RIP1-RIP3 cascade in LPS-induced ALI
  • Contributes to the functions of the laboratory
  • Administrative responsibilities


The Department of Pathology is part of UI Health Care, a comprehensive health sciences center that serves Iowa and the region, as well as patients referred from the United States and overseas. We are proud of our reputation for excellence in patient care, education and research. There is a long history of accomplishments in this storied department and we aim to build on this rich history toward continued excellence in the future. All these accomplishments are the fruits of the efforts of the faculty and staff in the department, who approach our mission with singular dedication, and the rich environment of UI Health Care that nurtures such success. https://medicine.uiowa.edu/pathology/


Our mission is to inspire and educate world class health care providers and scientists for the people of Iowa and our global community.

Researchers in the College's over 280 laboratories are served by state-of-the-art core research facilities and research support facilities. Much of the research conducted is interdisciplinary and collaborations are fostered and coordinated through major research centers, institutes and programs. Many faculty members are internationally renowned for their research. Two faculty members are Howard Hughes Institute Investigators, 12 are members of the Institute of Medicine and two are members of the National Academy of Sciences.


Percent of Time: 100%

Pay Range:  $50,012 - $62,000

This is a two-year specified term position, with the possibility of extension if additional funds are secured.


Benefits Highlights:

  • Regular salaried position located in Iowa City, Iowa
  • Fringe benefit package including paid vacation; sick leave; health, dental, life and disability insurance options; and generous employer contributions into retirement plans
  • For more information about Why Iowa?, click here

Required Qualifications

  • Requires a PhD degree in biological science and background knowledge in inflammation and cancer biology.
  • 2+ years of postdoctoral training experiences in the field of NF-kB signaling, inflammation and mouse xenograft tumor models.
  • Requires experience and IACUC knowledge in rodent colony management and caretaking, such as breeding, genotyping and euthanasia according to institutional regulations.  
  • Requires experience in molecular biology, including real-time RT-PCR, recombinant protein expression in E. coli, protein purification with affinity columns, gene expression in mammalian cells by lentiviral and retroviral vectors, western blot analysis of protein expression, immunohistochemistry, siRNA-mediated gene silencing, soft agar colony formation assays, and in vitro immunokinase assays using radioactive 32P-g-ATP.
  • Documented recent academic productivity (within the past 3 years) as evidenced as a primary or contributing author in peer reviewed academic/research publications.



Application Process: In order to be considered, applicants must upload a cover letter and CV/resume (under submission relevant materials) that clearly address how they meet the listed required and desired qualifications of this position.


Job openings are posted for a minimum of 14 calendar days.


Successful candidates will be subject to a criminal background check and should be prepared to submit 5 professional references upon request.

Equal opportunity/affirmative action employer

The University of Iowa is an equal opportunity/affirmative action employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, national origin, age, sex, pregnancy, sexual orientation, gender identity, genetic information, religion, associational preference, status as a qualified individual with a disability, or status as a protected veteran.

Persons with disabilities who need assistance or accommodations with the application or interview process may contact University Human Resources/Faculty and Staff Disability Services, (319) 335-2660 or fsds@uiowa.edu.  For jobs in UI Health care, please contact UI Health care Leave & Disability Administration at 319-356-7543.

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