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Research Associate - Anatomy and Cell Biology (Engelhardt Lab)

21001529 Requisition #

The Carver College of Medicine Department of Anatomy and Cell Biology is seeking a Research Associate to investigate the pathophysiology and biology of lung disease in animal and cell culture models. This position will be in the Engelhardt lab.


Duties to Include:


  • Research – Conduct laboratory experiments in a variety of settings and areas (molecular and cellular biology, primary cell culture, and animal procedures, as detailed below) using methods designed by research staff in a cystic fibrosis (CF) laboratory.
    • The position is focused on a CF ferret animal model of lung disease and aims to identify key pathophysiologic aspects amenable for therapeutic intervention
    • Candidates must have:
      • Animal handling experience and be comfortable with animal experiments requiring sedation
      • Monitoring during data collection
      • Ability to work in rapid decision-making environment where the wellbeing of the study animal is paramount
      • Cell culture experience is required
    • Advanced imaging (both structural and functional), respiratory physiology, and bronchoscopy form core components of experiments with animals
    • Initially assist on protocols already established, but over time assist with development of new protocols and contribute to experimental design


  • Conduct Experiments – Assist with, and eventually perform, complex experiments on valuable adult CF ferrets, including anesthesia, IV/IP/SQ injection, aerosol delivery of candidate therapeutics, and collection of biological samples. Such samples include blood/plasma and bronchoalveolar lavage (BAL); also, advanced imaging and physiological experiments.
    • Standard biochemical, molecular, and cellular experiments will be required as well, which includes ELISA, quantitative PCR, protein quantification and preparation for quantitative proteomics in addition to standard Western blotting
    • Assistance in tissue processing/sectioning according to protocols, including immunofluorescence and in-situ hybridization using confocal microscopy


  • Administrative and Project Management – Organize laboratory samples and reagents in a systematic fashion. Prepare lab materials and reagents for shipping to various collaborating labs and corporations outside of UIowa as requested. Interface with collaborating companies and data exchange. Assist in preparing and/or cataloging reagents and supplies that are to be used communally by all members of the lab. Assist in the ordering of lab supplies and budget reconciliation. Assist with ACURF/IRB protocol development and monitor lab safety compliance.


  • Experiments, Investigations, Evaluations – Candidates must be able to learn to read and understand scientific protocols, arrange and plan daily activities to optimize efficiency and results, be familiar with a wide variety of equipment and techniques, and adhere to all safety guidelines. In time, develop and refine experimental protocols and provide insights into existing methods to optimize their utility for the project.


  • Analyze and Summarize Data; Prepare Reports; Contribute to Manuscripts and Publications – Keep abreast of relevant scientific literature and be able to independently design and execute experiments. Gather, analyze, interpret, and critically evaluate research data. Present work both formally to the entire laboratory group and informally as needed/indicated. Collect and record large amounts of data, while remaining organized and able to assist in organization of the lab in general with the PI. Collect and track data in an organized fashion so that results can be readily translated for publication in the scientific literature. Assist in the preparation of publications and present at local/national meetings.


  • Facilities and Equipment Management – Assist in the running, calibration, and maintenance of laboratory equipment. Test new equipment, troubleshoot, and resolve complex equipment failures and repairs.


  • Supervision/Staffing – Supervised directly by the principal investigator. May train, provide direction, assignments, and mentorship to research interns and students who rotate through the laboratory.


  • Collaboration and Embracing Diversity – Ability to work with a variety of individuals and groups in a constructive and civil manner while appreciating the unique contribution of individuals from varied cultures, race, creed, color, national origin, age, sex, disability, sexual orientation, and gender identity.


  • Positive Impact/Achieving Results – Ability to utilize existing resources and learning to achieve or exceed desired outcomes of current and future organizational goals/needs. Ability to demonstrate ethical behavior in diverse situations while producing results.


  • Service Excellence/Customer Focus – Ability to meet or exceed customer service needs and expectations and provide excellent service in a direct or indirect manner. Ability to effectively transmit and interpret information through appropriate communication with internal and external customers.


Percent of Time: 100%

Pay Grade: 4A - https://hr.uiowa.edu/pay/pay-plans/professional-and-scientific-pay-structure

Type of Position: Specified Term/ One Year


Benefits Highlights:

  • Regular salaried position located in Iowa City, Iowa
  • Fringe benefit package including paid vacation; sick leave; health, dental, life and disability insurance options; and generous employer contributions into retirement plans
  • For more information about Why Iowa?, click here


Required Qualifications:

  • Bachelor’s degree in a biomedical-related science or an equivalent combination of education and experience in relevant field of study
  • Minimum of two years relevant experience is required
  • Good working knowledge of basic laboratory techniques, including use of antibodies for assays such as ELISA, Western, immunostaining and cell culture is required
  • Experience in handling and conducting experiments on animals is required, as this position will have exposure to animal models
  • Knowledge of laboratory etiquette, strong interpersonal skills, and excellent written and verbal skills are also required
  • Basic computer skills including document formatting and page layout, advanced spreadsheet abilities, standard use of presentation software for communication of results during lab meetings, familiarity with various other standard applications (email, image processing, etc) are also necessary for success in this position


Desirable Qualifications:

  • Previous independent research experience and familiarity with basic laboratory techniques at a more advanced level (independence in performing ELISA, blots, tissue culture and immunostaining)
  • Additional experience with larger animal models is also desired
  • Master’s degree in biomedical-related science is highly desired


Application Process: In order to be considered, applicants must upload a CV or resume (under submission relevant materials) that clearly address how they meet the listed required and desired qualifications of this position.


Job openings are posted for a minimum of 14 calendar days.


Successful candidates will be subject to a criminal background check. This position is not eligible for University sponsorship for employment authorization.

Equal opportunity/affirmative action employer

The University of Iowa is an equal opportunity/affirmative action employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, national origin, age, sex, pregnancy, sexual orientation, gender identity, genetic information, religion, associational preference, status as a qualified individual with a disability, or status as a protected veteran.

Persons with disabilities who need assistance or accommodations with the application or interview process may contact University Human Resources/Faculty and Staff Disability Services, (319) 335-2660 or fsds@uiowa.edu.  For jobs in UI Health care, please contact UI Health care Leave & Disability Administration at 319-356-7543.

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